In the fast-paced world of biotech research, SLU-PP-332 ERR Agonist stands out as a precision tool for probing estrogen-related receptor pathways. Modern Aminos offers this high-purity compound exclusively for licensed researchers. By harnessing its unique agonist profile, labs can drive more accurate assay results, streamline workflows, and elevate data reliability. Moreover, the compound’s validated performance ensures consistent outcomes across multiple experiments.

What Is SLU-PP-332 ERR Agonist?

SLU-PP-332 is a small-molecule agonist designed to selectively activate estrogen-related receptors (ERRs). First synthesized for metabolic studies, it now serves as a versatile probe in oncology and endocrinology research. Its high binding affinity ensures clear receptor engagement, while minimal off-target activity reduces background noise in assays.

Interaction with Estrogen-Related Receptors

ERRs regulate genes tied to energy metabolism and mitochondrial function. When SLU-PP-332 binds, it induces receptor conformational shifts that promote cofactor recruitment. Researchers can then measure downstream gene expression changes with quantitative PCR or reporter assays. For detailed compound data, see the PubChem Compound Summary for SLU-PP-332.

Selectivity and Potency

Unlike broad-spectrum ligands, SLU-PP-332 exhibits nanomolar potency against ERRα, ERRβ, and ERRγ. Transitioning from micromolar research chemicals, labs see sharper dose–response curves and improved EC₅₀ values. Furthermore, its aqueous solubility minimizes vehicle interference, accelerating experimental timelines.

Scientific Evidence Supporting SLU-PP-332 ERR Agonist

Peer-reviewed data underscore SLU-PP-332’s reliability. In one study, activation of ERRα by SLU-PP-332 enhanced mitochondrial biogenesis markers by over 200%. Moreover, gene arrays revealed significant upregulation of oxidative phosphorylation genes.

Peer-Reviewed Studies

• Smith et al. demonstrated cardiovascular benefits in rodent models when ERRα was activated by SLU-PP-332.

• Zhao and colleagues reported improved glucose homeostasis after receptor stimulation in diabetic mice.

For an overview of the receptor family, consult the Wikipedia article on SLU-PP-332.

Research Implications

As evidence grows, SLU-PP-332’s role expands into metabolic disease models and cancer metabolism assays. Therefore, labs using this agonist can pioneer new therapeutic insights and publish high-impact findings.

Key Benefits for Research Applications

Implementing SLU-PP-332 delivers tangible advantages. Whether optimizing assay sensitivity or validating gene targets, researchers gain robust data with fewer repeats.

Enhanced Assay Sensitivity

SLU-PP-332 lowers detection thresholds in reporter gene assays. As a result, weak promoter activities become quantifiable. Moreover, its high purity eliminates batch-to-batch variation that plagues lower-grade agonists.

Improved Data Reproducibility

By standardizing receptor activation, labs observe less variability across replicates. Additionally, SLU-PP-332’s consistency across lots ensures long-term project continuity, reducing costly experimental delays.

Advanced Applications of SLU-PP-332

Beyond basic assays, SLU-PP-332 unlocks deeper investigations into cellular metabolism and gene regulation.

Cancer Metabolism Studies

ERRs play pivotal roles in tumor energy pathways. By applying SLU-PP-332, researchers can map metabolic reprogramming in cancer cells. This approach leads to novel biomarker identification and potential therapeutic targets.

Cardiac Function Research

ERRα influences cardiac muscle physiology. Investigators use SLU-PP-332 to examine mitochondrial function in cardiomyocytes. This work advances understanding of heart disease mechanisms and aids drug screening efforts.

Implementing SLU-PP-332 ERR Agonist in Your Lab

Integrating SLU-PP-332 into workflows requires adherence to best practices. Below are actionable steps to maximize results.

Best Practices for Handling

1. Dissolution: Dissolve in DMSO at 10 mM, then dilute into aqueous buffers.

2. Storage: Store aliquots at −20 °C in amber tubes to protect from light.

3. Pipetting: Use low-bind tips to prevent compound loss.

4. Aliquoting: Prepare single-use aliquots to avoid freeze–thaw cycles.

Recommended Assay Protocols

• Reporter Assays: Pre-treat cells with 1 µM SLU-PP-332 for 4 hours before luciferase readout.

• qPCR: Harvest RNA after 6 hours of treatment to capture peak gene induction.

• ChIP-seq: Crosslink chromatin post-treatment to map receptor binding sites.

• Metabolomics: Collect cell extracts after 12 hours to analyze metabolic flux changes.

Troubleshooting Common Issues

Even with a high-quality agonist, labs may encounter challenges. Address these efficiently to maintain data integrity.

Low Signal in Reporter Assays

• Check Concentration: Verify SLU-PP-332 stock concentration via UV absorbance.

• Optimize Cell Density: Seed cells at optimal confluence (60–80%) for uniform response.

• Control for Vehicle: Include DMSO-only controls to isolate compound effects.

Variability Between Lots

• Document Lot Numbers: Record supplier lot numbers in your lab notebook.

• Run Reference Assays: Include a standard reference sample across experiments to detect drift.

Safety and Compliance Considerations

Modern Aminos products, including SLU-PP-332 ERR Agonist, are strictly “Not for Human Consumption.” Researchers must follow institutional guidelines for handling research chemicals.

Not for Human Consumption

This compound is strictly for in vitro or animal studies. Therefore, ensure clear labeling and restricted access in your facility.

Storage and Disposal

• Storage: Keep in a dedicated chemical freezer at −20 °C.

• Disposal: Neutralize waste per local biosafety regulations. Always consult your environmental health and safety (EHS) office. For additional laboratory safety guidelines, refer to curemd.com.

Why Modern Aminos for SLU-PP-332 ERR Agonist

Selecting a reliable supplier is crucial. Aminos Research specializes in high-purity research chemicals, peptides, and SARMs tailored to licensed labs.

Quality Assurance

Every batch undergoes third-party HPLC and NMR validation. Consequently, you receive consistent potency and purity above 98%.

Dedicated Support

Our technical team offers application guidance and custom assay development tips. Therefore, you accelerate project timelines with expert assistance.

Future Perspectives & Innovations

Looking ahead, SLU-PP-332 continues to inspire cutting-edge research. As labs explore combination studies with co-activators or inhibitors, new insights into ERR biology will emerge. Moreover, integration with high-throughput screening platforms promises to scale discovery efforts across disease models.

Conclusion

In summary, SLU-PP-332 ERR Agonist from Modern Aminos empowers researchers with precise receptor activation, high assay sensitivity, and reproducible data. By following our outlined best practices, troubleshooting tips, and advanced applications, your lab can unlock new insights into ERR biology, metabolic regulation, and therapeutic innovation. Visit Modern Aminos today to order SLU-PP-332 ERR Agonist and elevate your research quality.