What is Zepbound?

Zepbound, a new medication approved by the FDA for weight management in adults with obesity, utilizes tirzepatide as its active ingredient. It functions as a dual GIP and GLP-1 receptor agonist, stimulating two hormone receptors: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This dual action not only slows down digestion, helping people feel fuller for longer, but also boosts metabolism, leading to better weight and blood sugar management than GLP-1 agonists alone. Zepbound is indicated for adults with a body mass index (BMI) of 30 or greater, or those with a BMI of 27 who also have a weight-related condition, such as high blood pressure or heart disease. It is administered as a self-injected medicine under the skin once weekly.

New GLP-1 drugs, like Zepbound, are becoming more effective in delivering long-term weight loss. With roughly 1 in 8 patients taking GLP-1s, we are likely to see the continued growth in usage for the next decade. Currently, Zepbound is more effective in weight loss than Wegoy, but both can provide effective solutions for weight management.

What is Wegovy?

Wegovy, functioning as a GLP-1 receptor agonist, is primarily prescribed for weight loss. It works by targeting the GLP-1 receptors, similar to semaglutide, the active ingredient in Ozempic and Wegovy. This mechanism helps in reducing hunger and aiding in weight control, making it suitable for long-term weight management in adults with obesity or overweight with weight-related health conditions.

FDA Approval

The FDA’s approval of Zepbound for weight management marks a significant milestone in obesity treatment. Zepbound, already marketed as Mounjaro for treating type 2 diabetes, is now recognized for its efficacy in weight management under the brand name Zepbound. This approval is based on Lilly’s clinical trial results, which indicate that Zepbound is one of the most effective weight management medications on the market. The approval of Zepbound could improve access for patients who have struggled to obtain obesity medications amid drug shortages.

How Are They Used?

Zepbound (Tirzepatide):

• Administration: Zepbound is administered as a self-injected medicine under the skin once weekly.
• Dosage: The dosage of Zepbound varies based on individual patient needs and healthcare provider recommendations.
• Duration of Action: Zepbound has a half-life of approximately 120 hours.
• Use in Diabetes Management and Weight Loss: While primarily approved for weight management, Zepbound’s dual mechanism of action also aids in regulating blood sugar levels, making it useful for patients with type 2 diabetes.

Wegovy (Semaglutide):

• Administration: Wegovy is also administered via injection.
• Dosage: Similar to Zepbound, the dosage of Wegovy is tailored to the patient’s needs.
• Duration of Action: Wegovy has a half-life of about 168 hours.
• Use in Diabetes Management and Weight Loss: Wegovy is primarily used for weight loss but also helps in controlling blood sugar levels, benefiting patients with type 2 diabetes.

Side Effects

Zepbound:

• Common Side Effects: Include nausea, diarrhea, decreased appetite, vomiting, constipation, indigestion, and stomach pain.

• Severe Side Effects: Pancreatitis, low blood sugar, kidney failure, allergic reactions, and gallbladder problems.

Wegovy:

• Common Side Effects: Nausea, vomiting, diarrhea, constipation, and upset stomach.
• Severe Side Effects: Pancreatitis, gallbladder problems, kidney problems, and the potential risk of thyroid tumors.

Both Zepbound and Wegovy share similar side effects, primarily gastrointestinal issues. However, the severity and frequency of these side effects can vary between the two drugs. Patients considering either medication should consult with their healthcare provider to understand the risks and benefits, especially in the context of their individual health profiles. Comparing the side effects of Zepbound and Wegovy.

 

Weight Loss Results

Zepbound (Tirzepatide):

In Lilly’s clinical trials, adults without diabetes who received the highest approved dosage of Zepbound lost 18% of their body weight on average compared to those who received a placebo.

People with type 2 diabetes saw a 12% body weight reduction at the same dosage.

One in three study participants taking the highest dose of Zepbound lost more than 58 pounds, or about 25% of their body weight, compared to about 1.5% of patients on placebo who lost the same amount.

Wegovy (Semaglutide):

Wegovy has demonstrated substantial weight loss in clinical trials.

In studies involving participants without diabetes, those on Wegovy experienced an average reduction of 12.4% of their baseline body weight.

This significant weight loss underscores Wegovy’s role as an effective weight management medication.

Comparison Table

Based on the information from LifeMD, here is a comparison table between Zepbound and Wegovy:

Feature	Zepbound (Tirzepatide)	Wegovy (Semaglutide)
Mechanism of Action	Dual GIP and GLP-1 receptor agonist	GLP-1 receptor agonist
Average Weight Loss	17 to 25 pounds (varies by dosage)	12.4% of baseline body weight
FDA Approval	Weight Management	Weight Management
Dosage Form	Injection	Injection
Cost	Approximately $1,060	Around $1,349 every four weeks

Choosing Between Zepbound vs Wegovy: Which is Right for You?

When deciding between Zepbound and Wegovy for weight loss, several factors should be considered:

Individual Health Profile: Consider any existing health conditions and how each medication might interact with them.

Weight Loss Goals: Assess which medication aligns better with your specific weight loss objectives.

Cost: Evaluate the cost of each medication and how it fits into your budget.

Side Effects: Consider the potential side effects and how they might impact your daily life.

Consultation with Healthcare Professionals: It’s essential to discuss with a healthcare provider to determine the most suitable medication for your needs.

These factors will help guide your decision-making process in choosing the most appropriate medication for your weight loss journey.

Choosing Between Zepbound vs Wegovy: Which is Right for You?

When considering Zepbound and Wegovy for weight loss, several factors come into play:

• Mechanism of Action: Zepbound, as a dual GIP and GLP-1 receptor agonist, offers a broader approach to weight loss by targeting two hormones. Wegovy, as a GLP-1 receptor agonist, focuses on one. This difference might impact the effectiveness and suitability for different individuals.
• Long-term Efficacy: According to Dr. Sue Decotiis, a New York physician specializing in weight management, studies have shown that people lost more fat over an extended period with tirzepatide (Zepbound) compared to semaglutide (Wegovy). She notes that in a clinical study, people taking semaglutide stopped losing weight after about a year, but those on tirzepatide did not. 
• Side Effects and Tolerability: Dr. Decotiis also mentions that Zepbound is better tolerated with fewer side effects compared to Wegovy. Understanding the side effect profile of each medication is crucial in making an informed decision.
• Individual Health Profile: Your overall health, any existing conditions, and how each medication might interact with them are important considerations.
• Guidance from Healthcare Professionals: Consulting with a healthcare provider who can monitor and guide you through the treatment is essential. Dr. Decotiis warns against just getting a prescription from online platforms without proper care.

Alternative Medications

Apart from Zepbound (tirzepatide) and Wegovy (semaglutide), there are several other medications available for weight loss, each with distinct characteristics. These include other GLP-1 receptor agonists like Saxenda (liraglutide) and Ozempic (also semaglutide), as well as different classes of weight management drugs such as Qsymia (phentermine and topiramate) and Contrave (naltrexone and bupropion). Each of these medications has its own unique mechanism of action, side effects, and efficacy profile. By comparing these alternatives to Zepbound and Wegovy, individuals can work with their healthcare providers to find the most suitable option for their specific weight loss journey.

Also, there are some natural remedies too like sauna baths equipped with the best sauna heaters that can complement the above for weight loss. 

Top of Form

What Experts Say about Wegovy vs Zepbound

Experts like Dr. Sue Decotiis emphasize the distinctiveness of Zepbound and Wegovy, despite being in the same drug family. She prefers tirzepatide for its superior results and better tolerability. However, she also stresses the importance of being under the care of an informed physician while on these medications, highlighting the need for careful monitoring.

Can You Switch Between Zepbound and Wegovy?

Switching between Zepbound and Wegovy should be considered carefully and under medical guidance. Both medications belong to the same drug class (GLP-1 receptor agonists) but have different mechanisms of action, with Zepbound being a dual GIP and GLP-1 receptor agonist. Factors such as individual response to the current medication, side effects experienced, and specific health goals should be taken into account. It’s crucial to consult with a healthcare provider to evaluate the suitability and safety of switching medications, as well as to understand the potential implications of such a change in treatment.

Conclusion

In conclusion, Zepbound and Wegovy represent two significant advancements in weight loss and diabetes management. Zepbound, with its dual action on GIP and GLP-1 receptors, offers a broader approach to weight loss and blood sugar regulation. Wegovy, primarily a GLP-1 receptor agonist, is effective in reducing hunger and aiding in weight control. Clinical trials have demonstrated the efficacy of both medications in weight management, with Zepbound showing a slightly higher efficacy in terms of weight loss. When choosing between these two medications, factors such as individual health profile, weight loss goals, side effects, and cost should be considered. Consulting with healthcare professionals is essential to determine the most suitable medication for individual needs. While both Zepbound and Wegovy offer promising results, the choice ultimately depends on individual circumstances and medical advice.